MACROCYCLIC COMPOUND AND USES THEREOF

• Main Authors: KISHI YOSHITO, KIRA KAZUNOBU, ITO KEN
• Format: Patent
• Language: English; Japanese
• Published: 05.03.2024
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

To provide novel macrocyclic compounds having tumor vascular remodeling effect and anti-CAF (Cancer Associated Fibroblasts) activity.SOLUTION: The present invention provides novel Compound (1) having tumor vascular remodeling effect and/or anti-CAF (Cancer Associated Fibroblasts) activity, or a pharmaceutically acceptable salt thereof, optionally in a pharmaceutically acceptable carrier, and medical uses thereof.SELECTED DRAWING: Figure 1 【課題】腫瘍血管リモデリング効果および抗ＣＡＦ(Cancer Associated Fibroblasts)（がん関連線維芽細胞）活性を有する新規大環状化合物を提供すること。【解決手段】本発明は、薬剤学的に許容される担体中にあってもよい、腫瘍血管リモデリング効果および／または抗ＣＡＦ(Cancer Associated Fibroblasts)（がん関連線維芽細胞）活性を有する新規化合物（１）またはその薬剤学的に許容される塩、ならびにこれらの医療上の使用を提供する。JPEG2024028872000047.jpg61129【選択図】図１