BISPECIFIC EGFR/C-MET ANTIBODIES

To provide a bispecific epidermal growth factor receptor (EGFR)/hepatocyte growth factor receptor (c-Met) antibody.SOLUTION: The present invention provides an isolated EGFR/c-Met antibody. In the bispecific antibody, a heavy chain variable region 1 (VH1) and a light chain variable region 1 (VL1) pai...

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Bibliographic Details
Main Authors JOOST NEIJSSEN, PAUL PARREN, MARK CHIU, SHERI MOORES, JANINE SCHUURMAN
Format Patent
LanguageEnglish
Japanese
Published 28.02.2024
Subjects
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Summary:To provide a bispecific epidermal growth factor receptor (EGFR)/hepatocyte growth factor receptor (c-Met) antibody.SOLUTION: The present invention provides an isolated EGFR/c-Met antibody. In the bispecific antibody, a heavy chain variable region 1 (VH1) and a light chain variable region 1 (VL1) pair to form a first antigen-binding site that specifically binds EGFR, and a heavy chain variable region 2 (VH2) and a light chain variable region 2 (VL2) pair to form a second antigen-binding site that specifically binds c-Met.SELECTED DRAWING: None 【課題】二重特異性上皮増殖因子受容体（ＥＧＦＲ）／肝細胞増殖因子受容体（ｃ－Ｍｅｔ）抗体を提供する。【解決手段】単離されたＥＧＦＲ／ｃ－Ｍｅｔ抗体であって、重鎖可変領域１（ＶＨ１）と軽鎖可変領域１（ＶＬ１）とが対合してＥＧＦＲと特異的に結合する第１の抗原結合部位を形成し、重鎖可変領域２（ＶＨ２）と軽鎖可変領域２（ＶＬ２）とが対合してｃ－Ｍｅｔと特異的に結合する第２の抗原結合部位を形成する、二重特異性抗体である。【選択図】なし
Bibliography:Application Number: JP20230203256