KV7 CHANNEL ACTIVATOR COMPOSITION AND USE METHOD

To provide a compound for treating Kv7-related diseases such as epilepsy, amyotrophic lateral sclerosis, various types of pain, hyperexcitability, dyskinesia, dystonia, mania and tinnitus.SOLUTION: Provided are an optionally substituted benzimidazol-1,2-yl amide represented by formula 11, and a phar...

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Bibliographic Details
Main Authors LYNN RESNICK, JAMES S HALE, SCOTT S HARRIED, DAVID E MARESKA, GEORGE T TOPALOV, CHARLES A FLENTGE, MICHAEL E BOZIK, JUSTIN K BELARDI
Format Patent
LanguageEnglish
Japanese
Published 28.02.2024
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:To provide a compound for treating Kv7-related diseases such as epilepsy, amyotrophic lateral sclerosis, various types of pain, hyperexcitability, dyskinesia, dystonia, mania and tinnitus.SOLUTION: Provided are an optionally substituted benzimidazol-1,2-yl amide represented by formula 11, and a pharmaceutical composition having a therapeutically effective amount of said compound and a pharmaceutically acceptable excipient.SELECTED DRAWING: None 【課題】てんかん、筋萎縮性側索硬化症、様々なタイプの疼痛、過興奮、ジスキネジア、ジストニア、躁病および耳鳴りなどのＫｖ７関連疾患を治療するための化合物を提供する。【解決手段】式１１によって表される任意に置換されたベンゾイミダゾール－１，２－イルアミド、そのような化合物の治療有効量と薬学的に許容される賦形剤を有する医薬組成物を提供する。JPEG2024026104000240.jpg51157【選択図】なし
Bibliography:Application Number: JP20230195267