MULTIPLEX PCR DETECTION OF ALK, RET, AND ROS FUSIONS

• Main Authors: DWIGHT KUO, CHITRA MANOHAR, XIAOJU MAX MA, TRUONG HUAN, ANN BEGOVICH, JAYA RAJAMANI, CINDY CHEUNG, GRANTLAND HILLMAN, ELLEN ORDINARIO, JAVELIN CHI, MICHAEL LEE
• Format: Patent
• Language: English; Japanese
• Published: 09.02.2024
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; ENZYMOLOGY; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; METALLURGY; MICROBIOLOGY; MUTATION OR GENETIC ENGINEERING; PROCESSES OF PREPARING SUCH COMPOSITIONS; SPIRITS; VINEGAR; WINE

To provide novel means for detection of gene fusions.SOLUTION: Provided herein are methods and compositions for multiplex detection of a large number of actionable gene fusions with very high sensitivity and specificity. The present methods and compositions can detect ALK, RET, and ROS1 gene fusions...