MULTIPLEX PCR DETECTION OF ALK, RET, AND ROS FUSIONS

To provide novel means for detection of gene fusions.SOLUTION: Provided herein are methods and compositions for multiplex detection of a large number of actionable gene fusions with very high sensitivity and specificity. The present methods and compositions can detect ALK, RET, and ROS1 gene fusions...

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Main Authors DWIGHT KUO, CHITRA MANOHAR, XIAOJU MAX MA, TRUONG HUAN, ANN BEGOVICH, JAYA RAJAMANI, CINDY CHEUNG, GRANTLAND HILLMAN, ELLEN ORDINARIO, JAVELIN CHI, MICHAEL LEE
Format Patent
LanguageEnglish
Japanese
Published 09.02.2024
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS OR TEST PAPERS THEREFOR
CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES
ENZYMOLOGY
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS
METALLURGY
MICROBIOLOGY
MUTATION OR GENETIC ENGINEERING
PROCESSES OF PREPARING SUCH COMPOSITIONS
SPIRITS
VINEGAR
WINE
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Summary:To provide novel means for detection of gene fusions.SOLUTION: Provided herein are methods and compositions for multiplex detection of a large number of actionable gene fusions with very high sensitivity and specificity. The present methods and compositions can detect ALK, RET, and ROS1 gene fusions, optionally in combination with other mutations and fusions.SELECTED DRAWING: None 【課題】遺伝子融合を検出するために新規な手段の提供【解決手段】非常に高い感受性および特異性で多数の実施可能な遺伝子融合を多重検出する方法および組成物を提供する。本発明の方法および組成物は、随意に他の突然変異および融合と組み合わせて、ＡＬＫ、ＲＥＴ、およびＲＯＳ１遺伝子融合を検出することができる。【選択図】なし
Bibliography:Application Number: JP20230206878