SUBSTITUTED DIAZAHETERO-BICYCLIC COMPOUND, AND USE OF THE SAME

• Main Authors: JOHANNA ANLAHR, UDO ALBUS, MARTINA DELBECK, KARL COLLINS, DORIS GEHRING, MORITZ BECK-BROICHSITTER, JANINE NICOLAI, BJOERN ROSENSTEIN, MUELLER THOMAS, MICHAEL HAHN, KLEMENS LUSTIG, NIELS LINDNER
• Format: Patent
• Language: English; Japanese
• Published: 09.02.2024
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; COMPOSITIONS THEREOF; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROCESSES OF PREPARING SUCH COMPOSITIONS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

To provide a novel substance that works as a strong and selective blocker of TASK-1 and TASK-3 channels, is therefore suitable for treatment and/or prevention of particularly sleep-related breathing disorder such as obstructive and central sleep apnea and snoring and breathing disorders including other disorders.SOLUTION: The present application relates to: a novel (imidazo[1,2-a]pyridine-3-yl)methyl-substituted diazahetero bicyclic compound; a method for preparing the compound;, a use thereof individually or in combination for treating and/or preventing a disease; and a use thereof in order to prepare a pharmaceutical preparation for treating and/or preventing a disease particularly for treating and/or preventing breathing disorders including a sleep-related breathing disorder such as obstructive sleep apnea and central sleep apnea and snoring. Further, the present application relates to a method for discovering a compound having TASK-1 and/or TASK-3 blocking properties.SELECTED DRAWING: None 【課題】TASK-1およびTASK-3チャネルの強力かつ選択的な遮断薬として作用し、よって、特に閉塞性および中枢性睡眠時無呼吸およびいびきなどの睡眠関連呼吸障害ならびに他の障害を含む呼吸障害の治療および／または予防に適している新規な物質を提供することが本発明の目的である。【解決手段】本出願は、新規な（イミダゾ［1,2－a］ピリジン－3－イル）メチル－置換ジアザヘテロ二環式化合物、その調製のための方法、疾患を治療および／または予防するための単独でのまたは組合せでのその使用、ならびに疾患を治療および／または予防するための、特に閉塞性睡眠時無呼吸および中枢性睡眠時無呼吸およびいびきなどの睡眠関連呼吸障害を含む呼吸障害を治療および／または予防するための医薬品を調製するためのその使用に関する。本出願はさらに、TASK-1および／またはTASK-3遮断特性を有する化合物を発見する方法に関する。【選択図】なし