CHIMERIC ANTIGEN RECEPTORS TARGETING CD70
To provide isolated antibodies which specifically bind to CD70, pharmaceutical compositions comprising the isolated antibodies for use in treatment of a cancer, and methods of producing anti-CD70 antibodies.SOLUTION: The invention provides an isolated antibody which specifically binds to CD70, with...
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06.02.2024
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Abstract | To provide isolated antibodies which specifically bind to CD70, pharmaceutical compositions comprising the isolated antibodies for use in treatment of a cancer, and methods of producing anti-CD70 antibodies.SOLUTION: The invention provides an isolated antibody which specifically binds to CD70, with a heavy chain variable (VH) region comprising three CDRs from the VH region comprising specific sequences, and a light chain variable (VL) region comprising three CDRs from the VL region shown in specific sequences, where each CDR is defined in accordance with the Kabat definition, the Chothia definition, the combination of the Kabat definition and the Chothia definition, the AbM definition, or the contact definition of the CDR.SELECTED DRAWING: Figure 1
【課題】CD70に特異的に結合する単離抗体、癌の治療における使用のための前記単離抗体を含む医薬組成物、および抗CD70抗体を産生する方法を提供する。【解決手段】特定配列を含む重鎖可変(VH)領域由来の三つのCDRを含む前記VH領域、および特定配列に示される軽鎖可変(VL)領域由来の三つのCDRを含む前記VL領域、ここで、各CDRは、Kabatの定義、Chothiaの定義、Kabat定義とChothia定義の組み合わせ、AbM定義、またはCDRの接触定義に従い規定される、CD70に特異的に結合する単離抗体を提供する。【選択図】図1 |
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AbstractList | To provide isolated antibodies which specifically bind to CD70, pharmaceutical compositions comprising the isolated antibodies for use in treatment of a cancer, and methods of producing anti-CD70 antibodies.SOLUTION: The invention provides an isolated antibody which specifically binds to CD70, with a heavy chain variable (VH) region comprising three CDRs from the VH region comprising specific sequences, and a light chain variable (VL) region comprising three CDRs from the VL region shown in specific sequences, where each CDR is defined in accordance with the Kabat definition, the Chothia definition, the combination of the Kabat definition and the Chothia definition, the AbM definition, or the contact definition of the CDR.SELECTED DRAWING: Figure 1
【課題】CD70に特異的に結合する単離抗体、癌の治療における使用のための前記単離抗体を含む医薬組成物、および抗CD70抗体を産生する方法を提供する。【解決手段】特定配列を含む重鎖可変(VH)領域由来の三つのCDRを含む前記VH領域、および特定配列に示される軽鎖可変(VL)領域由来の三つのCDRを含む前記VL領域、ここで、各CDRは、Kabatの定義、Chothiaの定義、Kabat定義とChothia定義の組み合わせ、AbM定義、またはCDRの接触定義に従い規定される、CD70に特異的に結合する単離抗体を提供する。【選択図】図1 |
Author | SILER PANOWSKI SURABHI SRIVATSA SRINIVASAN MATHILDE BRUNNHILDE DUSSEAUX SAI TAO NIRANJANA ADITI NAGARAJAN PARK YOON BARBRA JOHNSON SASU ROMAN ARIEL GALETTO THOMAS JOHN VAN BLARCOM |
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DocumentTitleAlternate | CD70を標的とするキメラ抗原受容体 |
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SubjectTerms | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE |
Title | CHIMERIC ANTIGEN RECEPTORS TARGETING CD70 |
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