CHIMERIC ANTIGEN RECEPTORS TARGETING CD70

• Main Authors: PARK YOON, BARBRA JOHNSON SASU, THOMAS JOHN VAN BLARCOM, SURABHI SRIVATSA SRINIVASAN, NIRANJANA ADITI NAGARAJAN, ROMAN ARIEL GALETTO, MATHILDE BRUNNHILDE DUSSEAUX, SAI TAO, SILER PANOWSKI
• Format: Patent
• Language: English; Japanese
• Published: 06.02.2024
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

To provide isolated antibodies which specifically bind to CD70, pharmaceutical compositions comprising the isolated antibodies for use in treatment of a cancer, and methods of producing anti-CD70 antibodies.SOLUTION: The invention provides an isolated antibody which specifically binds to CD70, with a heavy chain variable (VH) region comprising three CDRs from the VH region comprising specific sequences, and a light chain variable (VL) region comprising three CDRs from the VL region shown in specific sequences, where each CDR is defined in accordance with the Kabat definition, the Chothia definition, the combination of the Kabat definition and the Chothia definition, the AbM definition, or the contact definition of the CDR.SELECTED DRAWING: Figure 1 【課題】ＣＤ７０に特異的に結合する単離抗体、癌の治療における使用のための前記単離抗体を含む医薬組成物、および抗ＣＤ７０抗体を産生する方法を提供する。【解決手段】特定配列を含む重鎖可変（ＶＨ）領域由来の三つのＣＤＲを含む前記ＶＨ領域、および特定配列に示される軽鎖可変（ＶＬ）領域由来の三つのＣＤＲを含む前記ＶＬ領域、ここで、各ＣＤＲは、Ｋａｂａｔの定義、Ｃｈｏｔｈｉａの定義、Ｋａｂａｔ定義とＣｈｏｔｈｉａ定義の組み合わせ、ＡｂＭ定義、またはＣＤＲの接触定義に従い規定される、ＣＤ７０に特異的に結合する単離抗体を提供する。【選択図】図１