PROCESS FOR THE PREPARATION OF ILOPROST

To provide a process for the preparation of iloprost through new intermediates with good yields, isolation of iloprost in solid form, as well as preparation of the 16(S)-iloprost and 16(R)-iloprost isomers, and isolation of iloprost and 16(S)-iloprost in solid, crystalline form.SOLUTION: The present...

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Main Authors IMRE ROZSUMBERSZKI, IREN HORTOBAGYI, TAMAS BAN, ZSUZSANNA KARDOS, CSABA VARADI, TIBOR SZABO
Format Patent
LanguageEnglish
Japanese
Published 23.01.2024
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:To provide a process for the preparation of iloprost through new intermediates with good yields, isolation of iloprost in solid form, as well as preparation of the 16(S)-iloprost and 16(R)-iloprost isomers, and isolation of iloprost and 16(S)-iloprost in solid, crystalline form.SOLUTION: The present invention provides a process for the preparation of iloprost, represented by the following formulae.SELECTED DRAWING: None 【課題】新たな中間体を介する、収率が良好なイロプロストの製造、固体形態のイロプロストの単離、ならびに１６（Ｓ）－イロプロストおよび１６（Ｒ）－イロプロスト異性体の製造、ならびに固体の結晶性形態のイロプロストおよび１６（Ｓ）－イロプロストの単離のための方法を提供する。【解決手段】下式で示されるイロプロストの製造法等を提供する。TIFF2024009928000076.tif37144【選択図】なし
Bibliography:Application Number: JP20230176020