ANTIBACTERIAL DIPEPTIDE COMPOUND

To provide a compound that can be readily synthesized, exhibits antibacterial activity against Porphyromonas gingivalis being a pathogenic bacterium of periodontitis, with greater specificity, and exhibits increased stability against esterase as well as reduced cytotoxicity.SOLUTION: The present inv...

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Bibliographic Details
Main Authors TABETA KOICHI, NONAKA YUKARI, SAKAMOTO YASUMITSU, HIDAKA KOJI, SEKIYA MIZUKI
Format Patent
LanguageEnglish
Japanese
Published 19.01.2024
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SPECIFIC USE OF COSMETICS OR SIMILAR TOILETPREPARATIONS
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Summary:To provide a compound that can be readily synthesized, exhibits antibacterial activity against Porphyromonas gingivalis being a pathogenic bacterium of periodontitis, with greater specificity, and exhibits increased stability against esterase as well as reduced cytotoxicity.SOLUTION: The present invention provides a compound represented by a general formula (1) [where R1 is a halogen atom or a nitro group, and R2 is an alkoxy group or an acylamino group] or a salt thereof or a solvate thereof.SELECTED DRAWING: None 【課題】簡便に合成することができ、歯周病の原因菌であるPorphyromonas gingivalisに対してより特異的に抗菌活性を発揮し、エステラーゼに対する安定性がより高く、且つ細胞為害性がより低い化合物を提供すること。【解決手段】一般式（1）：TIFF2024008547000011.tif47170［式中：R1はハロゲン原子又はニトロ基を示す。R2はアルコキシ基又はアシルアミノ基を示す。］で表される化合物若しくはその塩又はそれらの溶媒和物。【選択図】なし
Bibliography:Application Number: JP20220110510