PYRROLOPYRIMIDINES AS CFTR POTENTIATORS

To provide compounds which are potentiators of cystic fibrosis transmembrane conductance regulator (CFTR), and are useful for treatment of cystic fibrosis (CF), asthma, bronchiectasis, chronic obstructive pulmonary disease (COPD), constipation, diabetes mellitus, dry eye disease, pancreatitis, rhino...

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Main Authors JOSEPH WALTER STROHBACH, ELBAUM DANIEL, DAVID CHRISTOPHER LIMBURG, CHRISTOPH WOLFGANG ZAPF, IVAN VIKTOROVICH EFREMOV, MATHIAS JOHN PAUL, ATLI THORARENSEN, LORI KRIM GAVRIN, RAJIAH ALDRIN DENNY
Format Patent
LanguageEnglish
Japanese
Published 26.12.2023
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:To provide compounds which are potentiators of cystic fibrosis transmembrane conductance regulator (CFTR), and are useful for treatment of cystic fibrosis (CF), asthma, bronchiectasis, chronic obstructive pulmonary disease (COPD), constipation, diabetes mellitus, dry eye disease, pancreatitis, rhinosinusitis, Sjogren's syndrome, and other CFTR associated disorders.SOLUTION: The invention employs compounds having the structure in the figure, and pharmaceutically acceptable salts thereof.SELECTED DRAWING: None 【課題】嚢胞性線維症膜コンダクタンス制御因子（ＣＦＴＲ）の増強物質であり、嚢胞性線維症（ＣＦ）、喘息、気管支拡張症、慢性閉塞性肺疾患（ＣＯＰＤ）、便秘、糖尿病、ドライアイ疾患、膵炎、鼻副鼻腔炎、シェーグレン症候群及び他のＣＦＴＲ関連障害の処置に有用である化合物を提供する。【解決手段】下記構造を有する化合物、又はその薬学的に許容できる塩を使用する。JPEG2023182694000360.jpg47165【選択図】なし
Bibliography:Application Number: JP20230169299