IMPLANTABLE DEPOTS FOR CONTROLLED RELEASE OF THERAPEUTIC AGENTS

• Main Authors: WANG HONGLEI, KARUN D NAGA, DANIEL BOON LIM SEET, MICHEAL FELDSTEIN, LUO JINGNAN, HANSON S GIFFORD III, STEPHEN W BOYD, TEU KOON KIAT, JACKIE JOE HANCOCK, PATRICK H RUANE
• Format: Patent
• Language: English; Japanese
• Published: 21.12.2023
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

To provide depots for treatment of postoperative pain via sustained, controlled release of a therapeutic agent.SOLUTION: In some embodiments, a depot may comprise a therapeutic region comprising an analgesic agent, and a control region comprising a bioresorbable polymer and a releasing agent mixed with the polymer. The releasing agent may be configured to dissolve when the depot is placed in vivo to form diffusion openings in the control region. The depot may be configured to be implanted at a treatment site in vivo and, while implanted, release the therapeutic agent at the treatment site for 3 or more days.SELECTED DRAWING: None 【課題】治療剤の持続した制御放出を介して術後疼痛を処置するためのデポーを提供すること。【解決手段】一部の実施形態では、デポーは、鎮痛薬を含む治療領域と、生体吸収生ポリマーおよびこのポリマーと混合された放出剤を含む制御領域とを含んでいてもよい。放出剤は、ｉｎ ｖｉｖｏでデポーが配置されたとき溶解して制御領域に拡散開口を形成するように構成されてもよい。デポーは、ｉｎ ｖｉｖｏで処置部位に埋め込まれ、埋め込まれている間、３日間以上にわたり処置部位で治療剤を放出するように構成されてもよい。【選択図】なし