POST-ANGIOPLASTY RESTENOSIS INHIBITOR, AND STENT OR BALLOON USED FOR POST-ANGIOPLASTY RESTENOSIS INHIBITION
To provide an agent that suppresses the proliferation of vascular smooth muscle cells and can inhibit restenosis, particularly restenosis after stent treatment.SOLUTION: A post-angioplasty restenosis inhibitor is prepared that contains dantrolene or a pharmaceutically acceptable salt thereof or a hy...
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Main Authors | , , , , , , , , |
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Format | Patent |
Language | English Japanese |
Published |
07.12.2023
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Subjects | |
Online Access | Get full text |
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Summary: | To provide an agent that suppresses the proliferation of vascular smooth muscle cells and can inhibit restenosis, particularly restenosis after stent treatment.SOLUTION: A post-angioplasty restenosis inhibitor is prepared that contains dantrolene or a pharmaceutically acceptable salt thereof or a hydrate thereof as an active ingredient. Preferably, the pharmaceutically acceptable salt is sodium salt. Additionally, an agent-elution stent or an agent-elution balloon is prepared, with its surface coated with an agent layer that contains dantrolene or a pharmaceutically acceptable salt thereof or a hydrate thereof.SELECTED DRAWING: None
【課題】本発明の課題は、血管平滑筋細胞の増殖を抑え、再狭窄、特にステント治療後の再狭窄を抑制可能な薬剤を提供することにある。【解決手段】ダントロレン又はその薬学上許容される塩あるいはそれらの水和物を有効成分とする血管形成術後の再狭窄の抑制剤を調製する。薬学上許容される塩がナトリウム塩であることが好ましい。また、ダントロレン又はその薬学上許容される塩あるいはそれらの水和物を含む薬剤層が表面にコーティングされた薬剤溶出ステント又は薬剤溶出バルーンを作製する。【選択図】なし |
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Bibliography: | Application Number: JP20220086500 |