OXO-SUBSTITUTED COMPOUND

• Main Authors: IKUMA YOHEI, UESUGI JUNICHIRO, KANAI TOSHIO, NOGUCHI YOSHIHIKO, MIZUKAMI YUKI, FUKAYA TAKAYUKI, MIZUSHIMA SHINGO, SUDA HITOSHI, SUNATSUKA TOSHIAKI, KOIKE SHOKO
• Format: Patent
• Language: English; Japanese
• Published: 24.11.2023
• Subjects: ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM; CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

To provide a novel compound that has an excellent β-lactamase inhibitory effect.SOLUTION: More specifically, there is provided a compound represented by a formula (1a), (1b) or (11) having an excellent β-lactamase inhibitory effect or a pharmaceutically acceptable salt thereof. By using this compound either alone or in combination with a β-lactam drug, a useful preventive or therapeutic agent for bacterial infections is provided. Also there are provided useful preventive or therapeutic agents for treating various diseases through the combined use with β-lactam drugs.SELECTED DRAWING: None 【課題】本発明は、優れたβ－ラクタマーゼ阻害作用を有する新規な化合物を提供することを課題とする。【解決手段】より特定すると、本発明は、優れたβ－ラクタマーゼ阻害作用を有する式（１ａ）、（１ｂ）または（１１）で表される化合物、またはその製薬学的に許容される塩を提供する。この化合物は、β－ラクタム系薬剤との併用もしくは単剤にて細菌感染症の有用な予防または治療剤を提供する。本発明はまた、種々の疾患のβ－ラクタム系薬剤との併用による治療のために有用な予防または治療剤を提供する。【選択図】なし