RISK DETERMINATION METHOD AND RISK DETERMINATION SYSTEM FOR ARRHYTHMIA OR ARRHYTHMIA-RELATED DISORDER

• Main Authors: ITO KAORU, MIYAZAWA KAZUO
• Format: Patent
• Language: English; Japanese
• Published: 24.11.2023
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; ENZYMOLOGY; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; METALLURGY; MICROBIOLOGY; MUTATION OR GENETIC ENGINEERING; PROCESSES OF PREPARING SUCH COMPOSITIONS; SPIRITS; VINEGAR; WINE

To provide a method and a system that can determine the risk of arrhythmia or arrhythmia-related disorder such as atrial fibrillation with high accuracy, which can be applied to a wide range of races.SOLUTION: A method for determining a subject's risk of arrhythmia or arrhythmia-related disorder includes the steps of: preparing a data list including the effect allele and effect size of genetic variations related to arrhythmia; obtaining subject's genetic information; calculating an arrhythmia risk score from the subject's genetic information on the basis of information in the data list on the effect allele and effect size of genetic variations related to arrhythmia; and determining an arrhythmia risk on the basis of the risk score. The data list is a data list in which the results of genome analysis of Western populations and the results of genome analysis of non-Western populations are combined through meta-analysis.SELECTED DRAWING: Figure 1 【課題】幅広い人種にわたって適用可能な、心房細動等の不整脈または不整脈関連障害のリスクを高精度で判定することのできる方法およびシステムを提供すること。【解決手段】対象者の不整脈または不整脈関連障害のリスクを判定するための方法であって、不整脈に関連する遺伝的変異の効果アレルと効果量を含むデータリストを準備する工程、対象者の遺伝情報を入手する工程、前記データリストの不整脈関連遺伝的変異の効果アレルと効果量に関する情報に基づき、対象者の遺伝情報から不整脈リスクスコアを算出する工程、および前記リスクスコアに基づき不整脈のリスクを判定する工程、を含み、前記データリストが欧米人集団のゲノム解析結果と欧米人以外の集団のゲノム解析結果をメタ解析により統合したデータリストであることを特徴とする、方法。【選択図】図１