METHOD RELATING TO SWEETNESS ENHANCEMENT

• Main Authors: HANSEN CHAD ALLEN, SLACK JAY PATRICK, SIMONS CHRISTOPHER TODD
• Format: Patent
• Language: English; Japanese
• Published: 06.11.2023
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; ENZYMOLOGY; FOODS OR FOODSTUFFS; FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J; HUMAN NECESSITIES; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; METALLURGY; MICROBIOLOGY; MUTATION OR GENETIC ENGINEERING; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL; PROCESSES OF PREPARING SUCH COMPOSITIONS; SPIRITS; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES; VINEGAR; WINE

To provide agents that can modulate the taste response in humans (such as a sweet taste enhancer), and methods for the identification thereof.SOLUTION: The present invention provides an agent that, when mixed at a concentration near or just below the sweetness threshold with a sweet tastant at a concentration above the sweetness threshold, enhances the sweetness of the admixture of the agent and the sweet tastant in a greater than additive manner compared to the sweetness of an admixture containing solely the sweet tastant or solely the agent, wherein the agent is identifiable by comparing a signal produced by an assay for activity of a taste receptor in the presence of the agent against a signal produced by an assay for activity of a taste receptor in the absence of the agent, wherein the assay for activity of a taste receptor comprises identifying agents that bind to the trans-membrane domain of a taste receptor while excluding agents that bind to the venus fly-trap domain of a taste receptor.SELECTED DRAWING: None 【課題】ヒトにおける味覚応答を調節することができる剤（甘味増強剤など）、およびその同定方法を提供する。【解決手段】剤が、甘味閾値以上の濃度の甘味物質と、甘味閾値の近傍または僅かに下の濃度で混合された場合に、前記剤と前記甘味物質との混合物の甘味を、前記甘味物質のみまたは前記剤のみ含有する混合物の甘味と比較して相加的以上に増強する剤であって、前記剤が、前記剤の存在下での味覚受容体の活性アッセイによって生成されるシグナルと前記剤の非存在下での味覚受容体の活性アッセイによって生成されるシグナルとを比較して同定可能であり、前記味覚受容体の活性アッセイが、味覚受容体のビーナスフライトラップドメインに結合する剤を除外しながら、味覚受容体の膜貫通ドメインに結合する剤を同定することを含む、前記剤を提供する。【選択図】なし