COMPOSITIONS COMPRISING 15-HEPE AND METHODS OF USING THE SAME

• Main Authors: DAVID COUGHLAN, JOHN CLIMAX
• Format: Patent
• Language: English; Japanese
• Published: 18.10.2023
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

To provide compositions and methods for the treatment and prevention of liver disease, arthritis, fibrosis, idiopathic pulmonary fibrosis, decreased insulin sensitivity, psoriasis, cancer (e.g., melanoma), neurodegenerative disorders (e.g., Huntington's disease), inflammatory diseases, adipocyte differentiation, conception or reproductive problems, pain, obesity, and sequelae thereof.SOLUTION: Diseases are treated or prevented by administering a pharmaceutical composition containing 15-hydroxyeicosapentaenoic acid (15-HEPE) or a pharmaceutically acceptable derivative thereof to a subject in need thereof.SELECTED DRAWING: None 【課題】肝臓疾患、関節炎、線維症、特発性肺線維症、インスリン感受性の低下、乾癬、癌（例えば、黒色腫）、神経変性障害（例えば、ハンチントン病）、炎症性疾患、脂肪細胞分化、受胎または生殖の問題、疼痛、肥満、及びそれらの続発症の治療、予防のための組成物、及び方法を提供する。【解決手段】１５－ヒドロキシエイコサペンタエン酸（１５－ＨＥＰＥ）またはその薬学的に許容可能な誘導体を含む薬学的組成物を、それを必要とする対象に投与することによって疾患を治療または予防する。【選択図】なし