BLOOD PURIFIER, BLOOD PURIFICATION DEVICE, AND ACTUATION METHOD OF BLOOD PURIFICATION DEVICE

• Main Authors: SADAHIRO SHIYOU, HARUHARA TAKASHI, YAMAGUCHI SATORU, HIWATARI MICHIO, KOBAYASHI KYOETSU
• Format: Patent
• Language: English; Japanese
• Published: 29.09.2023
• Subjects: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROMTHE BODY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE

To provide a blood purifier capable of executing large-volume filtration post-HDF with a displacement liquid amount of 20 L or more by reducing an albumin leakage amount and/or reducing fluctuations in transmembrane pressure differences.SOLUTION: There is provided a blood purifier in which a bundle of hollow fiber membranes with an inner diameter larger than 200 μm and 250 μm or less is put in a container at a filling rate of 55-70%. When predetermined bovine blood is subjected to a predetermined circulation test, 1)A) the sum total of a total protein leakage amount is 1.0 g or less per m2 of membrane area, and B) the ratio of transmembrane pressure differences (TMP240) 240 minutes after the circulation test is started to transmembrane pressure differences (TMP10) 10 minutes after the circulation test is started is 0.77 or more, or 2)A) the sum total of a total protein leakage amount is larger than 1.0 g and 2.5 g or less per m2 of membrane area, and B) TMP10/TMP240 is 0.80 or more.SELECTED DRAWING: None 【課題】置換液量２０Ｌ以上の大量濾過post-ＨＤＦを、アルブミン漏出量を小さくして、および／または膜間圧力差の変動を小さくして実施することを可能にする血液浄化器を提供する。【解決手段】内径が２００μｍよりも大きく、２５０μｍ以下である中空糸膜の束が容器内に５５％以上７０％以下の充填率で充填された血液浄化器であって、所定の牛血を用いて、所定の循環試験に付されたときに、１）Ａ）総蛋白漏出量の合計が、膜面積１ｍ２あたり１．０ｇ以下であり、かつＢ）循環試験開始後１０分の膜間圧力差（ＴＭＰ10）に対する、循環試験開始後２４０分の膜間圧力差（ＴＭＰ240）の比（ＴＭＰ10／ＴＭＰ240）が０．７７以上であるか、あるいは２）Ａ）総蛋白漏出量の合計が、膜面積１ｍ２あたり１．０ｇを超え２．５ｇ以下であり、かつＢ）ＴＭＰ10／ＴＭＰ240が０．８０以上である、血液浄化器。【選択図】なし