ANTI-MESOTHELIN ANTIBODY AND ANTIBODY DRUG CONJUGATE THEREOF

• Main Authors: XU QIAOYU, FANG JIANMIN, LI SHENJUN, WANG MINGXUE, YE HUI, HUANG CHANGJIANG, LUO WENTING, JIANG JING
• Format: Patent
• Language: English; Japanese
• Published: 27.09.2023
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

To provide an antibody drug conjugates targeting MSLN.SOLUTION: Provided is an antibody drug conjugate having the formula Ab-(L-D)n. In the formula, (a) Ab is a humanized antibody or a functional fragment thereof that specifically binds to MSLN; (b) L is a linker or is absent; (c) D is a therapeutic agent; and (d) n is 1, 2, 3, 4, 5, 6, 7, or 8. The antibody that specifically binds to MSLN comprises a heavy chain and a light chain. Here, (i) the heavy chain variable region of the heavy chain comprises a specific amino acid sequence; and (ii) the light chain variable region of the light chain comprises another specific amino acid sequence.SELECTED DRAWING: Figure 1 【課題】ＭＳＬＮを標的とする抗体薬物コンジュゲートを提供する。【解決手段】式Ａｂ－（Ｌ－Ｄ）ｎを有する抗体薬物コンジュゲートであって、式中、（ａ）ＡｂはＭＳＬＮに特異的に結合するヒト化抗体またはその機能的断片であり、（ｂ）Ｌはリンカーであるか、または存在せず、（ｃ）Ｄは治療剤であり、（ｄ）ｎは１、２、３、４、５、６、７または８であり、ＭＳＬＮに特異的に結合する前記抗体が重鎖および軽鎖を含み、（ｉ）前記重鎖の重鎖可変領域が特定のアミノ酸配列を含み、（ｉｉ）前記軽鎖の軽鎖可変領域が別の特定のアミノ酸配列を含む、抗体薬物コンジュゲートである。【選択図】図１