CHIMERIC ANTIGEN RECEPTORS TARGETING FLT3

To provide antibodies that specifically bind to FMS like tyrosine kinase 3 (FLT3), chimeric antigen receptors (CARs) that specifically bind to FLT3, and engineered immune cells that express such CARs.SOLUTION: Provided herein is a FMS-like tyrosine kinase 3 (FLT3)-specific chimeric antigen receptor...

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Bibliographic Details
Main Authors BARBRA JOHNSON SASU, YIK ANDY YEUNG, DANIELLE ELIZABETH DETTLING, CESAR ADOLFO SOMMER, MOUSTAFA MARC HAMZE
Format Patent
LanguageEnglish
Japanese
Published 27.09.2023
Subjects
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Summary:To provide antibodies that specifically bind to FMS like tyrosine kinase 3 (FLT3), chimeric antigen receptors (CARs) that specifically bind to FLT3, and engineered immune cells that express such CARs.SOLUTION: Provided herein is a FMS-like tyrosine kinase 3 (FLT3)-specific chimeric antigen receptor of a specific sequence comprising an extracellular ligand binding domain, a first transmembrane domain and an intracellular signaling domain, where the extracellular ligand binding domain comprises a single chain variable fragment (scFv) comprising a heavy chain variable (VH) region and a light chain variable (VL) region and having specific sequences.SELECTED DRAWING: None 【課題】ＦＭＳ様チロシンキナーゼ３（ＦＬＴ３）に特異的に結合する抗体、ＦＬＴ３に特異的に結合するキメラ抗原受容体（ＣＡＲ）、およびそのようなＣＡＲを発現する遺伝子操作された免疫細胞を提供する。【解決手段】細胞外リガンド結合ドメイン、第１の膜貫通ドメイン、および細胞内シグナル伝達ドメインを含むＦＭＳ様チロシンキナーゼ３特異的キメラ抗原受容体であって、前記細胞外リガンド結合ドメインは、重鎖可変（ＶＨ）領域および軽鎖可変（ＶＬ）領域を含む単鎖可変断片（ｓｃＦｖ）を含み、特定の配列を有するＦＭＳ様チロシンキナーゼ３（ＦＬＴ３）特異的キメラ抗原受容体を提供する。【選択図】なし
Bibliography:Application Number: JP20230095976