ANTIBODY MOLECULES TO PD-L1 AND USES THEREOF

• Main Authors: GERHARD JOHANN FREY, JENNIFER MARIE MATARAZA, GORDON JAMES FREEMAN, CHANG HWAI WEN, ARLENE HELEN SHARPE, GLENN DRANOFF
• Format: Patent
• Language: English; Japanese
• Published: 12.09.2023
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

To provide antibody molecules that specifically bind to human Programmed Death Ligand 1 (PD-L1) and uses thereof.SOLUTION: Provided herein are anti-human PD-L1 antibody molecules that include CDRs of heavy and light chains including specific amino acid sequences. Also provided are combination therapies including the anti-human PD-L1 antibody molecules, and methods to treat, prevent and/or diagnose cancerous or infectious conditions and disorders using the anti-PD-L1 antibody molecules.SELECTED DRAWING: Figure 3 【課題】ヒトプログラム死－リガンド１（ＰＤ－Ｌ１）に特異的に結合する抗体分子及びその利用方法を提供する。【解決手段】特定のアミノ酸配列を含む重鎖及び軽鎖のＣＤＲｓを含む抗ヒトＰＤ－Ｌ１抗体分子を提供する。抗ヒトＰＤ－Ｌ１抗体分子を含む併用療法、抗ＰＤ－Ｌ１抗体分子を使用して、がん性又は感染性状態及び障害を処置、予防及び／又は診断する方法も提供する。【選択図】図３