RNA INTERFERENCE AGENTS FOR GST-π GENE MODULATION

• Main Authors: MOHAMMAD AHMADIAN, JENS HARBORTH, TAKAHASHI HIROICHI, ZHANG JUN, AJINOMI KENJIRO, TERADA ERIKA, YING WENBIN
• Format: Patent
• Language: English; Japanese
• Published: 05.09.2023
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

To provide compounds, compositions and methods for modulating the expression of human GST-π using RNA interference.SOLUTION: The RNA interference molecules can be used in methods for preventing or treating diseases such as malignant tumor. Provided are a range of siRNA structures, having one or more nucleotides being modified or chemically-modified. Advantageous structures include siRNAs with 2'-deoxy nucleotides located in the seed region, as well as other nucleotide modifications.SELECTED DRAWING: Figure 1 【課題】RNA干渉を利用してヒトGST-πの発現を調節する化合物、組成物、及び、方法を提供する。【解決手段】RNA干渉分子は悪性腫瘍等の疾患の予防又は治療方法に利用できる。１以上の修飾又は化学的修飾ヌクレオチドを含む一連のsiRNAが提供され、有利な構造にはシード領域に2'デオキシヌクレオチド並びに他のヌクレオチド修飾を有するsiRNAが含まれる。【選択図】図１