REACTION DEVICE USING DROPLET METHOD, AND MANUFACTURING METHOD

• Main Authors: YANAGI NICHIKEI, FUKUYAMA TAKAHIDE, HYODO MAMORU
• Format: Patent
• Language: English; Japanese
• Published: 24.08.2023
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY; CHEMISTRY; METALLURGY; ORGANIC CHEMISTRY; PERFORMING OPERATIONS; PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL; THEIR RELEVANT APPARATUS; TRANSPORTING

To provide an efficient method using a droplet method in a flow reaction.SOLUTION: A reaction device has a reaction tube for performing a reaction of at least two substrates in a flow method, in the reaction tube, a sea-island structure composed of (i) a discontinuous phase containing a first droplet containing a first substrate, or the first substrate and a first solvent, and a second droplet containing a second substrate, or the second substrate and a second solvent, and (ii) a continuous phase containing no substrate and a liquid medium is formed, the reaction tube is curved, at least one apex of the reaction tube is positioned in a direction where gravity acts more than both the inlet and the outlet of the reaction tube, or in a direction opposite to the direction where the gravity acts, the first droplet and the second droplet are united by action of the gravity to form one united droplet, and the first substrate and the second substrate are brought into contact with each other and are reacted with each other.SELECTED DRAWING: Figure 1 【課題】フロー反応において、ドロプレット方式を利用した効率的な方法を提供する。【解決手段】少なくとも２種の基質の反応をフロー形式で行う反応チューブを有する反応装置であって、反応チューブ内において、（ｉ）第１基質を含むまたは第１基質および第１溶媒を含む第１ドロプレット、および第２基質を含むまたは第２基質および第２溶媒を含む第２ドロプレットを含む不連続相、および（ｉｉ）基質を含まず、液状媒体を含む連続相からなる海島構造を形成させ、反応チューブが湾曲しており、反応チューブの少なくとも一つの頂点が反応チューブの入口および出口の位置両方よりも重力が作用する方向または重力が作用する方向とは反対方向に位置しており、第１ドロプレットと第２ドロプレットが、重力の作用によって合体して、１つの合体ドロプレットを形成し、第１基質と第２基質が接触して反応する反応装置。【選択図】図１