HUMANIZED RODENTS FOR TESTING THERAPEUTIC AGENTS

• Main Authors: MCWHIRTER JOHN, COREY MOMONT, KEBBEDE ANTENEH, VERA VORONINA, LYNN MACDONALD, NAXIN TU
• Format: Patent
• Language: English; Japanese
• Published: 22.08.2023
• Subjects: AGRICULTURE; ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; FORESTRY; HUMAN NECESSITIES; HUNTING; HYGIENE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEDICAL OR VETERINARY SCIENCE; NEW BREEDS OF ANIMALS; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; TESTING; TRAPPING

To provide humanized rodents for testing therapeutic agents.SOLUTION: Provided herein are methods and compositions relating to the in vivo testing of therapeutic agents comprising a human Fc in genetically modified rodents (e.g., the testing of pharmacokinetic and/or pharmacodynamic properties of such a therapeutic agent in genetically modified rodents). In some embodiments, the genetically modified rodents express antibodies comprising a human Fc (e.g., a human IgG1 Fc, a human IgG4 Fc). In some embodiments, the rodents express fully human antibodies (i.e., antibodies having human heavy chains and human light (γ or κ) chains).SELECTED DRAWING: Figure 1A 【課題】治療薬を試験するためのヒト化げっ歯類の提供。【解決手段】本明細書で提供されるのは、遺伝子改変されたげっ歯類における、ヒトＦｃを含む治療薬のｉｎ ｖｉｖｏ試験（例えば、遺伝子改変されたげっ歯類における、かかる治療薬の薬物動態及び／または薬力学的特性の試験）に関する方法及び組成物である。いくつかの実施形態では、遺伝子改変されたげっ歯類は、ヒトＦｃ（例えば、ヒトＩｇＧ１ Ｆｃ、ヒトＩｇＧ４ Ｆｃ）を含む抗体を発現する。いくつかの実施形態では、げっ歯類は、完全ヒト抗体（すなわち、ヒト重鎖及びヒト軽鎖（γまたはκ）を有する抗体）を発現する。【選択図】図１Ａ