METHOD FOR PRODUCING MORPHINAN DERIVATIVE

• Main Author: HIROSE MASAAKI
• Format: Patent
• Language: English; Japanese
• Published: 17.08.2023
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

To provide a method for producing a morphinan derivative.SOLUTION: The invention provides a production method for obtaining a morphinan derivative represented by a general formula (II) in the figure by means of a reduction reaction using a formic acid or the like. In the formula, R1 represents a hydrogen atom or the like; R2 and R3 each represent a hydrogen atom, an optionally substituted C1-10 alkyl group, or the like; R4, R5 and R6 are the same or different and each represent a hydrogen atom or the like; R7 represents a hydrogen atom, an optionally substituted C1-10 alkyl group, or the like; and R8 represents an optionally substituted C1-10 alkyl group, an optionally substituted aralkyl group, or the like.SELECTED DRAWING: None 【課題】モルヒナン誘導体の製造方法を提供する。【解決手段】ギ酸等を用いた還元反応による、次の一般式（ＩＩ）（式中、Ｒ１は水素原子等、Ｒ２及びＲ３は水素原子、置換基を有していてもよいＣ１－１０アルキル基等、Ｒ４、Ｒ５、Ｒ６は同一又は異なって水素原子等、Ｒ７は水素原子、置換基を有していてもよいＣ１－１０アルキル基等、Ｒ８は置換基を有していてもよいＣ１－１０アルキル基、置換基を有していてもよいアラルキル基等を表す。）で表されるモルヒナン誘導体を得る製造方法。JPEG2023113976000048.jpg51110【選択図】なし