COMPOSITIONS AND METHODS FOR MODULATING HBV AND TTR EXPRESSION

To provide modified oligonucleotides. and compounds with conjugate groups.SOLUTION: In a compound, a modified oligonucleotide consists of 8-80 linked nucleosides and has a nucleobase sequence that is at least 85%, 90%, 95% or 100% complementary to a sequence encoding transthyretin.SELECTED DRAWING:...

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Bibliographic Details
Main Authors SETH PUNIT P, PRAKASH THAZHA P, SWAYZE ERIC E
Format Patent
LanguageEnglish
Japanese
Published 16.08.2023
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SPIRITS
VINEGAR
WINE
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Summary:To provide modified oligonucleotides. and compounds with conjugate groups.SOLUTION: In a compound, a modified oligonucleotide consists of 8-80 linked nucleosides and has a nucleobase sequence that is at least 85%, 90%, 95% or 100% complementary to a sequence encoding transthyretin.SELECTED DRAWING: None 【課題】修飾オリゴヌクレオチドおよび共役基を含む化合物を提供する。【解決手段】修飾オリゴヌクレオチドが、８～８０個の連結したヌクレオシドからなり、かつトランスサイレチンをコードする配列に少なくとも８５％、９０％、９５％、または１００％相補的な核酸塩基配列を有する、化合物である。【選択図】なし
Bibliography:Application Number: JP20230093703