ANTIBODIES AGAINST ILT2 AND USES THEREOF
To provide a monoclonal antibody or an antigen binding portion thereof that binds to a human ILT2 epitope within the sequence of human leukocyte immunoglobulin-like receptor subfamily B member 1 (ILT2), as well as a pharmaceutical composition and method for producing same.SOLUTION: Provided is a mon...
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Main Authors | , , , , , , , , , |
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Format | Patent |
Language | English Japanese |
Published |
26.07.2023
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Subjects | |
Online Access | Get full text |
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Summary: | To provide a monoclonal antibody or an antigen binding portion thereof that binds to a human ILT2 epitope within the sequence of human leukocyte immunoglobulin-like receptor subfamily B member 1 (ILT2), as well as a pharmaceutical composition and method for producing same.SOLUTION: Provided is a monoclonal antibody or antigen-binding fragment that has three heavy chain CDRs (CDR-H) and three light chain CDRs (CDR-L) of specific sequences and that binds to ILT2 and inhibits ILT2-mediated immune cell suppression.SELECTED DRAWING: None
【課題】ヒト白血球免疫グロブリン様受容体サブファミリーBメンバー1(ILT2)の配列内のヒトILT2エピトープに結合する、モノクローナル抗体またはその抗原結合性部分、ならびにそれを含む医薬組成物およびそれを生成する方法を提供する。【解決手段】特定の配列からなる3つの重鎖CDR(CDR-H)および3つの軽鎖CDR(CDR-L)を有し、ILT2に結合しILT2媒介免疫細胞抑制を阻害する、モノクローナル抗体または抗原結合性断片を提供する。【選択図】なし |
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Bibliography: | Application Number: JP20230081165 |