METHODS FOR PREDICTING RISK OF DEVELOPING PULMONARY COLONIZATION/INFECTION BY PSEUDOMONAS AERUGINOSA

• Main Authors: MARLENE KERAVEC, STANISLAS MONDOT, JEROME MOUNIER, GENEVIEVE HERY-ARNAUD, PATRICIA LEPAGE, CHARLES-ANTOINE GUILLOUX
• Format: Patent
• Language: English; Japanese
• Published: 19.07.2023
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; ENZYMOLOGY; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; METALLURGY; MICROBIOLOGY; MUTATION OR GENETIC ENGINEERING; PROCESSES OF PREPARING SUCH COMPOSITIONS; SPIRITS; VINEGAR; WINE

To provide methods for predicting the risk of developing pulmonary colonization/infection with Pseudomonas aeruginosa.SOLUTION: Respiratory tract microbiota from sputum samples of 65 patients are analyzed to compare the microbiota data, and it is found that patients who will remain uninfected with Pseudomonas aeruginosa have 3-times higher abundance of Porphyromonas than the other groups. Specifically, a method for predicting the risk of developing pulmonary colonization/infection with Pseudomonas aeruginosa in a subject suffering from cystic fibrosis (CF) comprises measuring the abundance of Porphyromonas genus bacteria in a biological sample obtained from the subject.SELECTED DRAWING: None 【課題】緑膿菌による肺定着／感染の発現リスクを予測する方法を提供する。【解決手段】６５人の患者の痰サンプル由来の気道微生物叢を分析し、微生物叢データを比較し、緑膿菌に非感染のままであろう患者では、他の群と比べてポルフィロモナス属の存在量が３倍多いことを見出した。具体的には、嚢胞性線維症（CF）に罹患している被験体における緑膿菌による肺定着／感染の発現リスクを予測する方法であって、該被験体から得られた生物学的サンプル中のポルフィロモナス属の細菌の存在量を測定することを含む方法を開示する。【選択図】なし