CONFINED AND CONDITIONALLY ACTIVATED BINDING PROTEIN

• Main Authors: ROBERT B DUBRIDGE, MAIA VINOGRADOVA, ANAND PANCHAL, CHAD MAY
• Format: Patent
• Language: English; Japanese
• Published: 04.07.2023
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

To provide a protein for treating cancer which is selectively activated in the presence of tumor protease.SOLUTION: Protein includes a first antigen binding domain binding a human tumor target antigen, a first domain linker, a confined Fv domain including a first variable heavy domain, a confined non-cleavable linker and a first variable light domain, a second domain linker, a second antigen binding domain, a cleavable linker, and a confined pseudo Fv domain including a first pseudo light variable domain, a non-cleavable linker and a first pseudo heavy variable domain, and includes a third domain linker, and a third antigen binding domain binding human serum albumin.SELECTED DRAWING: None 【課題】腫瘍プロテアーゼの存在下で選択的に活性化されるがんの治療のためのタンパク質を提供する。【解決手段】ヒト腫瘍標的抗原に結合する第１の抗原結合ドメインと、第１のドメインリンカーと、第１の可変重ドメイン、拘束非開裂性リンカー、ならびに第１の可変軽ドメインを含む拘束Ｆｖドメインと、第２のドメインリンカーと、第２の抗原結合ドメインと、開裂性リンカーと、第１の偽軽可変ドメイン、非開裂性リンカー、及び第１の偽重可変ドメインを含む拘束偽Ｆｖドメインとを含み、第３のドメインリンカーと、ヒト血清アルブミンに結合する第３の抗原結合ドメインと、を含む、タンパク質とする。【選択図】なし