COMPOUNDS AND METHODS TARGETING INTERLEUKIN-34

• Main Authors: ANDREW DIXON SKORA, YE MING, ADAM S FLEISHER, ALBERT LO, SARAH ELISABETH RAINES, ROBIN ELIZABETH WALSH, MARK MINTUN, ELIZABETH ANNE WEST, MARCIO CHEDID, MEGAN BRITTANY LANNAN, VICTOR H OBUNGU, JOHN RANDALL SIMS II
• Format: Patent
• Language: English; Japanese
• Published: 16.05.2023
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

To provide antibodies, compounds, pharmaceutical compositions and methods for treating immune-mediated diseases such as Alzheimer's disease or tauopathy diseases.SOLUTION: Provided herein is an antibody that binds to human IL-34, where the antibody comprises a heavy chain variable region (VH) and a light chain variable region (VL), the VH comprises a heavy chain complementarity determining region (HCDR) HCDR1, HCDR2 and HCDR3, and the VL comprises a light chain complementarity determining region (LCDR) LCDR1, LCDR2 and LCDR3. Also provided is an agent for treating an immune-mediated disease selected from the group consisting of Alzheimer's disease, a tauopathy disease, Sjogren syndrome (SS), rheumatoid arthritis (RA), inflammatory bowel disease (IBD), atopic dermatitis, kidney diseases, sepsis, and/or non-alcoholic fatty liver disease (NAFLD).SELECTED DRAWING: None 【課題】アルツハイマー病又はタウオパチー疾患などの免疫介在性疾患を治療するための抗体、化合物、医薬組成物及び方法を提供する。【解決手段】ヒトＩＬ－３４に結合する抗体であって、前記抗体が、重鎖可変領域（ＶＨ）と、軽鎖可変領域（ＶＬ）と、を含み、前記ＶＨが、重鎖相補性決定領域（ＨＣＤＲ）ＨＣＤＲ１、ＨＣＤＲ２、及びＨＣＤＲ３を含み、前記ＶＬが、軽鎖相補性決定領域（ＬＣＤＲ）ＬＣＤＲ１、ＬＣＤＲ２、及びＬＣＤＲ３を含む、抗体を提供する。また、前記抗体を含む、アルツハイマー病、タウオパチー病、シェーグレン症候群（ＳＳ）、関節リウマチ（ＲＡ）、炎症性腸疾患（ＩＢＤ）、アトピー性皮膚炎、腎疾患、敗血症、及び／又は非アルコール性脂肪性肝疾患（ＮＡＦＬＤ）からなる群から選択される免疫介在性疾患の治療剤を提供する。【選択図】なし