KETOAMIDE DERIVATIVES AS PROTEASE INHIBITORS

To provide ketoamide derivative compounds having main protease (Mpro) inhibitory activity and useful for the treatment or prevention of the risk of disorders, diseases, and sequelae caused by viral infections; pharmaceutical compositions comprising these compounds; and the use of these compounds and...

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Main Authors YAMAGUCHI RYUICHI, FUKUMOTO YUTAKA, NOGUCHI HIROHIDE, YAMAGISHI TATSUYA, ITSUMI YOSHIAKI, MAGARA RYOHEI
Format Patent
LanguageEnglish
Japanese
Published 04.01.2023
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:To provide ketoamide derivative compounds having main protease (Mpro) inhibitory activity and useful for the treatment or prevention of the risk of disorders, diseases, and sequelae caused by viral infections; pharmaceutical compositions comprising these compounds; and the use of these compounds and compositions in the prevention or treatment of diseases caused by viruses including coronaviruses.SOLUTION: Compounds represented by the general formula (I) are used.SELECTED DRAWING: None 【課題】本発明は、メインプロテアーゼ(Mpro)阻害活性を有し、ウイルス感染によって引き起こされる、障害、疾患、および後遺症のリスクの治療または予防に有用であるケトアミド誘導体化合物、これらの化合物を含む医薬組成物、ならびにコロナウイルスを含むウイルスによって引き起こされる疾患の予防または治療におけるこれらの化合物および組成物の使用を提供することを課題とする。【解決手段】一般式（Ｉ）で表される化合物を使用する。TIFF2023000996000145.tif56154【選択図】なし
Bibliography:Application Number: JP20220004720