T-CELL RECEPTOR EXPRESSED BY HUMAN T-CELLS THAT RECOGNIZE PEPTIDE DERIVED FROM URLC10 OR PEPTIDE DERIVED FROM DEPDC1

• Main Authors: NAGIRA MORIO, DOI KEIJI, YAMASHITA SACHIKO, IDE NOBUYUKI, PARK JAE-HYUN, HIKICHI TETSURO
• Format: Patent
• Language: English; Japanese
• Published: 28.12.2022
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; COMPOSITIONS THEREOF; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; CULTURE MEDIA; ENZYMOLOGY; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PROCESSES OF PREPARING SUCH COMPOSITIONS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; VINEGAR; WINE

To provide a T-cell receptor (TCR) that has URLC10- or DEPDC1-specific HLA-A24-restricted cytotoxic activity.SOLUTION: The present invention provides: a T-cell receptor containing CDR3 having a specific amino acid sequence; a polynucleotide encoding the T-cell receptor; an expression vector containing the polynucleotide; a composition for inducing a cytotoxic T-cell containing the expression vector; a cytotoxic T-cell transformed with the expression vector; and a method for monitoring the induction of a cytotoxic T-cell including the step for determining an amino acid sequence of CDR3 of a T-cell receptor of a peripheral blood lymphocyte taken from a subject that has been treated to induce a cytotoxic T-cell of URLC10 or DEPDC1.SELECTED DRAWING: None 【課題】ＵＲＬＣ１０またはＤＥＰＤＣ１特異的なＨＬＡ－Ａ２４拘束性の細胞傷害活性を有するＴ細胞受容体（ＴＣＲ）の提供。【解決手段】特定のアミノ酸配列を有するＣＤＲ３を含むＴ細胞受容体、前記Ｔ細胞受容体をコードするポリヌクレオチド、前記ポリヌクレオチドを含む発現ベクター、前記発現ベクターを含む細胞傷害性Ｔ細胞の誘導用組成物、前記発現ベクターで形質転換された細胞障害性Ｔ細胞、および、ＵＲＬＣ１０またはＤＥＰＤＣ１の細胞傷害性Ｔ細胞の誘導処置を受けた対象から採取された末梢血リンパ球のＴ細胞受容体のＣＤＲ３のアミノ酸配列を決定する工程を含む細胞傷害性Ｔ細胞の誘導をモニタリングする方法。【選択図】なし