NERVE CELLS AND APPLICATIONS THEREOF

To provide neurons undergoing tau aggregation and cell death; a screening kit and a screening method using the nerve cells; a drug candidate substance obtained by the screening method; human pluripotent stem cells for producing the nerve cells; and a method for producing the nerve cells.SOLUTION: Pr...

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Bibliographic Details
Main Authors MAEDA SUMIHIRO, TANABE HIROKAZU, OKANO HIDEYUKI, ENDO SETSU
Format Patent
LanguageEnglish
Japanese
Published 14.10.2022
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS OR TEST PAPERS THEREFOR
COMPOSITIONS THEREOF
CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES
CULTURE MEDIA
ENZYMOLOGY
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PROCESSES OF PREPARING SUCH COMPOSITIONS
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Summary:To provide neurons undergoing tau aggregation and cell death; a screening kit and a screening method using the nerve cells; a drug candidate substance obtained by the screening method; human pluripotent stem cells for producing the nerve cells; and a method for producing the nerve cells.SOLUTION: Provided are neurons with introduced exogenous wild-type tau gene.SELECTED DRAWING: None 【課題】タウ凝集と細胞死を起こす神経細胞；上記神経細胞を用いたスクリーニングキット及びスクリーニング方法；上記スクリーニング方法により得られる薬剤候補物質；上記神経細胞を製造するためのヒト多能性幹細胞；及び上記神経細胞の製造方法、を提供すること。【解決手段】導入された外因性野生型タウ遺伝子を有する神経細胞。【選択図】なし
Bibliography:Application Number: JP20210061794