METHOD FOR MEASURING ANTI-DRUG ANTIBODY

• Main Authors: OMORI AKANE, SEKINO TETSUO
• Format: Patent
• Language: English; Japanese
• Published: 14.10.2022
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; ENZYMOLOGY; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; METALLURGY; MICROBIOLOGY; MUTATION OR GENETIC ENGINEERING; PHYSICS; PROCESSES OF PREPARING SUCH COMPOSITIONS; SPIRITS; TESTING; VINEGAR; WINE

To provide a simple and inexpensive method for measuring an anti-drug antibody as compared with a conventional method.SOLUTION: Provided is a double antigen cross-linking immunoassay using the capture nucleic acid and the tracer nucleic acid. By using the capture nucleic acid and the tracer nucleic acid in a double antigen cross-linking immunoassay method, the measurement of an anti-drug antibody can be performed simply and inexpensively. Also, by using the tracer nucleic acid, a highly sensitive detection method using nucleic acid can be employed.SELECTED DRAWING: Figure 1-4 【課題】従来法と比較して、簡便かつ安価な抗薬物抗体の測定法を提供する。【解決手段】捕獲核酸及びトレーサー核酸を使用する二重抗原架橋イムノアッセイ法を提供する。二重抗原架橋イムノアッセイ法において捕獲核酸及びトレーサー核酸を使用することにより、抗薬物抗体の測定を簡便かつ安価に行うことができる。また、トレーサー核酸を使用することにより、核酸を利用した高感度検出方法を採用することが可能になる。【選択図】図１－４