4-FLUORO-3,5-DIALKOXY ANILINE DERIVATIVE AND METHOD FOR PRODUCING SYNTHETIC INTERMEDIATE THEREOF

To provide a method for producing a 4-fluoro-3,5-dialkoxy aniline derivative and a synthetic intermediate thereof in high yield.SOLUTION: This invention relates to a method for producing a compound represented by the general formula [1], including the step for reacting 3,4,5-trifluoroaniline with MO...

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Bibliographic Details
Main Authors HASABA SATOSHI, DATE MUTSUHIRO, IUCHI TORU
Format Patent
LanguageEnglish
Japanese
Published 13.10.2022
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
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Summary:To provide a method for producing a 4-fluoro-3,5-dialkoxy aniline derivative and a synthetic intermediate thereof in high yield.SOLUTION: This invention relates to a method for producing a compound represented by the general formula [1], including the step for reacting 3,4,5-trifluoroaniline with MOR1 (R1 is a C1-6 alkyl group and M is alkali metal atom) at 110-140°C and 0.3-0.9 MPa. (In the general formula [1], R1 is as defined above and two R1's are the same groups).SELECTED DRAWING: None 【課題】 4-フルオロ-3,5-ジアルコキシアニリン誘導体及びその合成中間体を高い収率で得るための製造方法の提供を課題とする。【解決手段】 本発明は、110～140℃且つ0.3～0.9MPaの条件下で、3,4,5-トリフルオロアニリンをＭＯＲ１（Ｒ１は、炭素数１～６のアルキル基を表し、Ｍはアルカリ金属原子を表す。）と反応させる工程を有する、下記一般式［１］で示される化合物の製造方法等に関する。TIFF2022154958000016.tif2854（一般式［１］中、Ｒ１は上記と同じであり、２つのＲ１は同一の基を表す。）【選択図】なし
Bibliography:Application Number: JP20210058237