COMPOSITION FOR TREATING INFLAMMATORY BOWEL DISEASE

• Main Authors: IIJIMA HIDEKI, KAYAMA HISAKO, TAKEDA KIYOSHI, TAKEHARA TETSURO, OTAKE YURIKO
• Format: Patent
• Language: English; Japanese
• Published: 06.10.2022
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MUTATION OR GENETIC ENGINEERING; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROCESSES OF PREPARING SUCH COMPOSITIONS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

To provide compositions capable of treating inflammatory bowel disease, and to provide a screening method for substances for treating inflammatory bowel disease.SOLUTION: Provided is a composition for treating inflammatory bowel disease containing a substance inhibiting the function of a lysophosphatidylserine receptor or its downstream intracellular signaling substance, or a composition for inhibiting hyperactivation of Th1 cells in intestinal mucosa. A preferred lysophosphatidylserine receptor is P2Y10 and signal transduction pathways downstream of P2Y10 include a Rho/ROCK signaling pathway. Provided is a screening method comprising measuring the activity of inhibiting the function of lysophosphatidylserine receptors on Th1 cells, or a screening method comprising measuring the activity of inhibiting the function of a downstream signaling substance.SELECTED DRAWING: Figure 21 【課題】炎症性腸疾患を治療できる組成物を提供すること、および、炎症性腸疾患を治療するための物質のスクリーニング方法を提供することを課題とする。【解決手段】リゾホスファチジルセリン受容体またはその下流の細胞内シグナル伝達物質の機能を抑制する物質を含有する炎症性腸疾患治療用組成物、または、腸粘膜におけるＴｈ１細胞の過剰活性化を抑制するための組成物を提供する。好適なリゾホスファチジルセリン受容体はＰ２Ｙ１０であり、Ｐ２Ｙ１０の下流のシグナル伝達経路としてＲｈｏ／ＲＯＣＫシグナルが挙げられる。Ｔｈ１細胞上のリゾホスファチジルセリン受容体の機能を抑制する活性を測定する工程を含むスクリーニング方法、または、その下流のシグナル伝達物質の機能を抑制する活性を測定する工程を含むスクリーニング方法を提供する。【選択図】図２１