SCHIZOPHYLLAN LIPOSOME, AND METHOD FOR PREPARING AND USE OF THE SAME

• Main Authors: SASAKI KIMIO, HU LU, SUN HUAIQING, PU YAN, WANG JUAN, PEI YUNLIN, GUO CHAOWAN, WANG LIHUA, NIE YANFENG
• Format: Patent
• Language: English; Japanese
• Published: 17.05.2022
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC USE OF COSMETICS OR SIMILAR TOILETPREPARATIONS

To provide a schizophyllan liposome, and a method for preparing the liposome and use thereof.SOLUTION: A method for preparing a schizophyllan liposome includes: a step (1) of dissolving lipid into organic solvent, and removing organic solvent to form a lipid membrane; a step (2) of mixing the lipid membrane obtained in step (1) with schizophyllan, surfactant and buffer solution, hydrating until the lipid membrane separates to form milky-white liquid to obtain crude suspension liquid of a schizophyllan liposome; and a step (3) of treating the crude suspension liquid of the schizophyllan liposome obtained in step (2) by ultrasonic waves, and filtering the liquid by a filtration film to obtain the schizophyllan liposome.SELECTED DRAWING: Figure 1 【課題】シゾフィラン（ｓｃｈｉｚｏｐｈｙｌｌａｎ）リポソーム及びその調製方法と使用を提供する。【解決手段】脂質を有機溶媒に溶解し、有機溶媒を除去し、脂質膜を形成するステップ（１）と、ステップ（１）で得られた脂質膜をシゾフィラン、界面活性剤、及び緩衝液と混合し、脂質膜が分離して乳白色の液体を形成するまで水和し、シゾフィランリポソームの粗製懸濁液を得るステップ（２）と、ステップ（２）で得られたシゾフィランリポソームの粗製懸濁液を超音波処理し、濾過膜で濾過して前記シゾフィランリポソームを得るステップ（３）とを含む、ことを特徴とするシゾフィランリポソームの調製方法による。【選択図】図１