METHOD FOR PRODUCING ISOINDOLINONE DERIVATIVE

• Main Authors: HAYASHI YUKI, SHIOZAWA MOTOKI, TAKAHASHI YUSUKE, SEKI MASAHIKO
• Format: Patent
• Language: English; Japanese
• Published: 07.02.2022
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; METALLURGY; ORGANIC CHEMISTRY

To provide a method for producing isoindolinone derivatives with high production efficiency.SOLUTION: A method includes bringing, in the presence of a cobalt catalyst and sodium percarbonate, an amide derivative and a carbon monoxide source compound including an azo derivative into contact with each other, resulting in an isoindolinone derivative of the following formula (3), where R1 is a halogen atom, a nitro group, a nitrile group, a substituted or unsubstituted alkyl group, a substituted or unsubstituted alkoxy group or the like; R2 and R3 independently represent a hydrogen atom, a halogen atom, a nitro group, a nitrile group, a substituted or unsubstituted alkyl group or the like.SELECTED DRAWING: None 【課題】生産効率の高いイソインドリノン誘導体の製造方法を提供する。【解決手段】コバルト触媒及び過炭酸ナトリウム存在下、アミド誘導体と、アゾ誘導体を含む一酸化炭素源化合物とを接触させて、下記式（３）で表されるイソインドリノン誘導体を得る、方法である。JPEG2022022957000024.jpg3298式中、Ｒ１は、ハロゲン原子、ニトロ基、ニトリル基、置換若しくは非置換のアルキル基、置換若しくは非置換のアルコキシ基等、Ｒ２及びＲ３は、独立に、水素原子、ハロゲン原子、ニトロ基、ニトリル基、置換若しくは非置換のアルキル基等を表す。【選択図】なし