LIQUID-FILLED HARD CAPSULE FORMULATION

To provide a liquid-filled hard capsule formulation that can contain more active ingredients than when the liquid filling to be encapsulated in the capsule is a non-aqueous solvent and that requires no addition of ingredients other than an active ingredient, such as a capsule stabilizer.SOLUTION: Th...

Full description

Saved in:
Bibliographic Details
Main Authors HATANAKA JUNYA, HAMADA KENICHI
Format Patent
LanguageEnglish
Japanese
Published 13.01.2022
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
Online AccessGet full text

Cover

More Information
Summary:To provide a liquid-filled hard capsule formulation that can contain more active ingredients than when the liquid filling to be encapsulated in the capsule is a non-aqueous solvent and that requires no addition of ingredients other than an active ingredient, such as a capsule stabilizer.SOLUTION: The present invention is a liquid-filled hard capsule formulation with improved stability. The formulation comprises a liquid in which a quaternary ammonium compound and/or an amino acid is dissolved in a polar solvent as an active ingredient. The liquid is formulated by filling it in a hard capsule composed of a cellulose derivative.SELECTED DRAWING: None 【課題】カプセル剤に封入する液体充填物が非水系溶媒であるときと比較して有効成分を多く配合でき、かつ、カプセルの安定化剤のような有効成分以外の成分を添加する必要がない液体充填ハードカプセル製剤を提供する。【解決手段】本発明は、有効成分として第４級アンモニウム化合物および／又はアミノ酸を極性溶媒に溶解した液体をセルロース誘導体で構成される硬カプセルに充填して製剤化したことを特徴とする、安定性の改善された液体充填ハードカプセル製剤である。【選択図】なし
Bibliography:Application Number: JP20200108534