FACTOR VIII CHIMERIC AND HYBRID POLYPEPTIDES, AND METHODS OF USE THEREOF

To provide factor VIII chimeric and hybrid polypeptides as well as methods of use thereof.SOLUTION: The present invention provides a method of administering a factor VIII (a processed FVIII, a single strand FVIII or combinations thereof); a method of administering a chimeric and hybrid polypeptide i...

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Main Authors SUSAN LOW, BYRON MCKINNEY, MATT OTTMER, LI LIAN, HAIYAN JIANG, JURG SOMMER, ROBERT PETERS, KAREN NUGENT, GLENN PIERCE, BITONTI ALAN J, ALVIN LUK, JENNIFER A DUMONT
Format Patent
LanguageEnglish
Japanese
Published 11.01.2022
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:To provide factor VIII chimeric and hybrid polypeptides as well as methods of use thereof.SOLUTION: The present invention provides a method of administering a factor VIII (a processed FVIII, a single strand FVIII or combinations thereof); a method of administering a chimeric and hybrid polypeptide including a factor VIII; a chimeric and hybrid polypeptide including a factor VIII; a polynucleotide encoding such chimeric and hybrid polypeptide; cells containing such polynucleotide; as well as a method of producing such chimeric and hybrid polypeptide using such cells.SELECTED DRAWING: None 【課題】第ＶＩＩＩ因子キメラおよびハイブリッドポリペプチドならびにその使用法を提供すること。【解決手段】本発明は、第ＶＩＩＩ因子（プロセシングされたＦＶＩＩＩ、一本鎖ＦＶＩＩＩ、またはそれらの組み合わせ）を投与する方法、第ＶＩＩＩ因子を含むキメラおよびハイブリッドポリペプチドを投与する方法、第ＶＩＩＩ因子を含むキメラおよびハイブリッドポリペプチド、そのようなキメラおよびハイブリッドポリペプチドをコードするポリヌクレオチド、そのようなポリヌクレオチドを含む細胞、ならびにそのような細胞を用いてそのようなキメラおよびハイブリッドポリペプチドを産生する方法を提供する。【選択図】なし
Bibliography:Application Number: JP20210170188