PYRAZOLOPYRIDINE DERIVATIVE HAVING GLP-1 RECEPTOR AGONIST EFFECT

• Main Authors: MATSUO ATSUSHI, OGAWA HIROKO, NISHIMURA SACHIKAZU, KASHIWAGI HIROTAKA, YOSHIDA MASANOBU, NISHIMOTO MASAHIRO, FURUTA YOSHIYUKI, YOSHINO HITOSHI, KAWAI TAKAHIRO, SATO TSUTOMU, TANIDA TOMOTSUGU, AOKI MASAHIDE, HORI NOBUYUKI, SHIRAISHI TAKUYA, KAMON TAKUMA, TSUCHIYA TOMOHITO, OGURI KYOKO
• Format: Patent
• Language: English; Japanese
• Published: 11.01.2022
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

To provide a compound that has the same effect as GLP-1, as a GLP-1 receptor agonist, and a preventative agent or therapeutic agent for non-insulin-dependent diabetes mellitus (type 2 diabetes) or obesity containing the compound.SOLUTION: The present invention provides: a compound represented by Formula (I) in which an indole ring or pyrrolo[2,3-b]pyridine ring and a pyrazolopyridine backbone are bound through a substituent, or a salt thereof, or a solvate of them; and a preventative agent or therapeutic agent for non-insulin-dependent diabetes mellitus (type 2 diabetes), obesity or the like containing them as an active ingredient.SELECTED DRAWING: None 【課題】ＧＬＰ−１受容体アゴニストとしてＧＬＰ−１と同様の作用を有する化合物、該化合物を含有するインスリン非依存性糖尿病（２型糖尿病）または肥満症の予防剤または治療剤を提供する。【解決手段】インドール環又はピロロ［２，３−ｂ］ピリジン環とピラゾロピリジン骨格が置換基を介して結合した、式（Ｉ）で表される化合物もしくはその塩、またはそれらの溶媒和物、並びに、それらを有効成分として含有する、インスリン非依存性糖尿病（２型糖尿病）または肥満症等の予防剤または治療剤を提供する。【選択図】なし