CYCLOBUTYL DIHYDROQUINOLINE SULFONAMIDE COMPOUNDS

To provide cyclobutyl dihydroquinoline sulfonamide compounds.SOLUTION: The present invention provides a compound of Formula (I) in the figure, an enantiomer, diastereoisomer or atropisomer thereof, a mixture thereof, or a pharmaceutically acceptable salt thereof, which inhibits voltage-gated sodium...

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Bibliographic Details
Main Authors BENJAMIN C MILGRAM, ISAAC E MARX, ALAN H CHERNEY, WANG HAOXUAN
Format Patent
LanguageEnglish
Japanese
Published 27.12.2021
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:To provide cyclobutyl dihydroquinoline sulfonamide compounds.SOLUTION: The present invention provides a compound of Formula (I) in the figure, an enantiomer, diastereoisomer or atropisomer thereof, a mixture thereof, or a pharmaceutically acceptable salt thereof, which inhibits voltage-gated sodium channels, in particular Nav1.7 and is useful for treatment of diseases associated with the activity of sodium channels such as pain disorders, cough and itch.SELECTED DRAWING: None 【課題】シクロブチルジヒドロキノリンスルホンアミド化合物を提供する。【解決手段】式（Ｉ）の化合物；その鏡像異性体、ジアステレオ異性体、アトロプ異性体、その混合物、又はその薬学的に許容される塩を提供し、これは、電位開口型ナトリウムチャネル、特にＮａｖ１．７を阻害する。疼痛障害、咳嗽、痒みなどのナトリウムチャネル活性と関連する疾患の治療に有用である。【選択図】なし
Bibliography:Application Number: JP20210090960