ARYL RECEPTOR MODULATORS AND METHODS OF MAKING AND USING THE SAME

• Main Authors: FRANCESCA VITI, SALVATORE BELLINVIA, SALVATORE DEMARTIS
• Format: Patent
• Language: English; Japanese
• Published: 09.12.2021
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

To provide an aryl receptor modulators and methods of making and using the same.SOLUTION: The present invention is generally directed towards compounds capable of binding the aryl hydrocarbon receptor and modulating its activity, methods of treating inflammatory conditions such as Crohn's disease using such compounds, and pharmaceutical compositions comprising such compounds. Also provided are methods of increasing levels of IL-22 in a subject and/or decreasing levels of IFN-γ in a subject. An inflammatory disease or condition treated by the compounds of the invention is selected from the group consisting of inflammatory bowel disease, cartilage inflammation, bone degradation, ulcerative colitis, psoriasis, arthritis, psoriatic arthritis, rheumatoid arthritis, juvenile arthritis, juvenile rheumatoid arthritis, autoimmune hepatitis, Crohn's disease, lupus erythematosus, multiple sclerosis, Alzheimer's disease, dermatitis, atopic dermatitis, acne, Type I diabetes mellitus, Raynaud's phenomenon, Graves' disease, and Addison's disease.SELECTED DRAWING: None 【課題】アリール受容体モジュレーターならびにその作製および使用方法を提供すること。【解決手段】本発明は、一般に、アリール炭化水素受容体を結合し、その活性をモジュレートすることができる化合物、このような化合物を使用するクローン病などの炎症状態を処置する方法、およびこのような化合物を含む医薬組成物を対象とする。また、被験体のＩＬ−２２レベルを増大し、かつ／または被験体のＩＦＮ−γレベルを低減する方法が提供される。本発明の化合物によって処置される炎症性疾患または状態は、炎症性腸疾患、軟骨の炎症、骨分解、潰瘍性大腸炎、乾癬、関節炎、乾癬性関節炎、関節リウマチ、若年性関節炎、若年性関節リウマチ、自己免疫性肝炎、クローン病、紅斑性狼瘡、多発性硬化症、アルツハイマー病、皮膚炎、アトピー性皮膚炎、ざ瘡、Ｉ型真性糖尿病、レイノー現象、グレーブス病、およびアジソン病からなる群より選択される。【選択図】なし