NITROGEN-CONTAINING SPIROCYCLIC COMPOUNDS AND PHARMACEUTICAL USES THEREOF

To provide novel nitrogen-containing spirocyclic compounds and pharmaceutical uses thereof.SOLUTION: The present invention provides a compound represented by the general formula [I] in the figure, where each symbol is as defined herein, or a pharmaceutically acceptable salt thereof or a solvate ther...

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Main Authors SHIOZAKI MAKOTO, MIURA TOMOYA, YAMANAKA HIROSHI, MAEDA KATSUYA, INOUE AKIFUMI, HARA YOSHINORI, NOMICHI SATORU, HORI AKIMI, HASE YASUNORI
Format Patent
LanguageEnglish
Japanese
Published 02.12.2021
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:To provide novel nitrogen-containing spirocyclic compounds and pharmaceutical uses thereof.SOLUTION: The present invention provides a compound represented by the general formula [I] in the figure, where each symbol is as defined herein, or a pharmaceutically acceptable salt thereof or a solvate thereof, and a pharmaceutical use of the same in treating organ transplant rejection, graft versus host reaction after transplantation, autoimmune disease, allergic disease and chronic myeloproliferative disease.SELECTED DRAWING: None 【課題】本発明は、新規含窒素スピロ環化合物及びその医薬用途に関する。【解決手段】下記一般式［Ｉ］で示される化合物又はその医薬上許容される塩、或いはその溶媒和物、並びにその臓器移植時の拒絶、移植後の対宿主性移植片反応、自己免疫疾患、アレルギー性疾患及び慢性骨髄増殖性疾患治療の医薬用途。（式中、各記号は明細書に記載のとおりである）【選択図】なし
Bibliography:Application Number: JP20210144545