CYTOSTATIC AGENT AND PHARMACEUTICAL COMPOSITION FOR TREATING OR PREVENTING CANCER CONTAINING THE SAME

• Main Author: NIITSU YOSHIRO
• Format: Patent
• Language: English; Japanese
• Published: 02.12.2021
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MUTATION OR GENETIC ENGINEERING; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROCESSES OF PREPARING SUCH COMPOSITIONS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; TESTING; VINEGAR; WINE

To provide drugs capable of inhibiting cell proliferation effectively in cancer cells.SOLUTION: The cytostatic agent for cancer, in which RAS/RAF/MEK/ERK signaling cascade is activated, of the present invention contains a GSTP1 inhibiting agent in combination with a drug inhibiting RAS/RAF/MEK/ERK signaling cascade, and the cytostatic agent for cancer, in which RAS/RAF/MEK/ERK signaling cascade is activated, of the invention contains a drug inhibiting the interaction between GSTP1 and CRAF.SELECTED DRAWING: None 【課題】がん細胞において効果的に細胞増殖を抑制することができる薬剤の提供。【解決手段】GSTP1を抑制する薬物と、RAS/RAF/MEK/ERKシグナルカスケードを抑制する薬物とを組み合わせて含む、RAS/RAF/MEK/ERKシグナルカスケードが活性化されているがんに対する細胞増殖抑制剤、及びGSTP1とCRAFの相互作用を阻害する薬物を含む、RAS/RAF/MEK/ERKシグナルカスケードが活性化されているがんに対する細胞増殖抑制剤。【選択図】なし