AQUEOUS SUSPENSION AGENT

To provide a technique for producing an aqueous suspension agent containing brimonidine and/or its salt, brinzolamide and/or its salt and a carboxyvinyl polymer.SOLUTION: There is provided an aqueous suspension agent containing brimonidine and/or its salt, brinzolamide and/or its salt and a carboxyv...

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Bibliographic Details
Main Author SUGIHARA RYO
Format Patent
LanguageEnglish
Japanese
Published 16.09.2021
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:To provide a technique for producing an aqueous suspension agent containing brimonidine and/or its salt, brinzolamide and/or its salt and a carboxyvinyl polymer.SOLUTION: There is provided an aqueous suspension agent containing brimonidine and/or its salt, brinzolamide and/or its salt and a carboxyvinyl polymer, in which the increase in the particle diameter with time of suspension particles (brinzolamide and/or its salt) in the aqueous suspension agent can be suppressed by using a carboxyvinyl polymer having an anti-salt viscosity maintenance rate measured under the conditions shown in the specification of 18% or less as the carboxyvinyl polymer.SELECTED DRAWING: None 【課題】本発明の目的は、ブリモニジン及び／又はその塩と、ブリンゾラミド及び／又はその塩と、カルボキシビニルポリマーとを含む水性懸濁剤の製造技術を提供することである。【解決手段】ブリモニジン及び／又はその塩と、ブリンゾラミド及び／又はその塩と、カルボキシビニルポリマーを含む水性懸濁剤において、当該カルボキシビニルポリマーとして、明細書に示す条件で測定される対塩粘度維持率が１８％以下のものを選択することにより、水性懸濁剤における懸濁粒子（ブリンゾラミド及び／又はその塩）の粒子径の経時的な増大を抑制できる。【選択図】なし
Bibliography:Application Number: JP20210034952