COMPOSITION FOR EXTERNAL USE

To provide compositions for external use with improved stability of a heparinoid, and to provide compositions for external use with improved formulation stability.SOLUTION: We have found that by compounding a heparinoid and tranexamic acid, the stability of the heparinoid in the composition for exte...

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Bibliographic Details
Main Authors OGATA MAYUMI, KARANIHARA TORU, TAKEUCHI NOBUYUKI
Format Patent
LanguageEnglish
Japanese
Published 16.09.2021
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SPECIFIC USE OF COSMETICS OR SIMILAR TOILETPREPARATIONS
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Summary:To provide compositions for external use with improved stability of a heparinoid, and to provide compositions for external use with improved formulation stability.SOLUTION: We have found that by compounding a heparinoid and tranexamic acid, the stability of the heparinoid in the composition for external use can be improved and the decomposition of the components over time can be suppressed. We have also found that additionally compounding placenta extract suppresses precipitation. That is, the present invention is a composition for external use characterized by containing (a) a heparinoid and (b) tranexamic acid or a salt thereof. Further, it is preferable to contain (c) placenta extract.SELECTED DRAWING: None 【課題】本発明の課題は、本発明の目的はヘパリン類似物質の安定性が向上している外用組成物を提供することである。また、製剤安定性が向上している外用組成物を提供することである。【解決手段】ヘパリン類似物質とトラネキサム酸とを配合することにより、外用組成物中でヘパリン類似物質の安定性が向上し、経時的な成分の分解を抑制できることを見出した。また、さらにプラセンタエキスを配合すると、析出を抑制することを見出した。すなわち、（ａ）ヘパリン類似物質、（ｂ）トラネキサム酸又はその塩を含有することを特徴とする外用組成物である。さらに（ｃ）プラセンタエキスを含有することが好ましい。【選択図】なし
Bibliography:Application Number: JP20200214032