COMPOSITIONS FOR MAINTAINING FILTRATION BLEB

To identify a compound having no activity of suppressing the growth of corneal epithelial cells and having an activity of suppressing the growth of fibroblasts, in order to safely maintain the filtration bleb formed by a glaucoma filtering surgical method for a long period of time.SOLUTION: It is di...

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Bibliographic Details
Main Authors SHIMAZAKI ATSUSHI, SATO KOUTA, AKAISHI TAKAHIRO, NAKAMURA MASATANE, NAKAZAWA TORU
Format Patent
LanguageEnglish
Japanese
Published 08.07.2021
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:To identify a compound having no activity of suppressing the growth of corneal epithelial cells and having an activity of suppressing the growth of fibroblasts, in order to safely maintain the filtration bleb formed by a glaucoma filtering surgical method for a long period of time.SOLUTION: It is discovered that amsacrine has no activity of suppressing the growth of corneal epithelial cells and has an activity of suppressing the growth of fibroblasts and is useful for safely maintaining the filtration bleb formed by a glaucoma filtering surgical method for a long period of time.SELECTED DRAWING: None 【課題】 緑内障濾過手術法にて形成された濾過胞を、安全性高く、長く維持するため、角膜上皮細胞の増殖を抑制する活性を有さず、かつ線維芽細胞の増殖を抑制する活性を有する化合物を同定する。【解決手段】 アムサクリンが、角膜上皮細胞の増殖を抑制する活性を有さず、かつ線維芽細胞の増殖を抑制する活性を有することを見出し、緑内障濾過手術法にて形成された濾過胞を、安全性高く、長く維持する上で有用であることも明らかにした。【選択図】 なし
Bibliography:Application Number: JP20210065108