PREPARATION METHOD OF PYRIMIDINYL CYCLOPENTANE COMPOUND

• Main Authors: REINHARD REENTS, MICHELANGELO SCALONE, FRANCIS GOSSELIN, HANS IDING
• Format: Patent
• Language: English; Japanese
• Published: 08.07.2021
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; ENZYMOLOGY; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

To provide a preparation method of a pyrimidinyl cyclopentane compound useful as an intermediate in preparation of an AKT protein kinase inhibitor having therapeutic activity against diseases such as a cancer.SOLUTION: A preparation method of a pyrimidinyl cyclopentane compound couples a carboxylic acid derivative having optical activity produced by asymmetric hydrogenation using a metal catalyst with an alcohol derivative having optical activity produced by asymmetric reduction catalyzed by a redox enzyme.SELECTED DRAWING: None 【課題】癌などの疾患に対する治療活性を有するＡＫＴプロテインキナーゼ阻害薬の調製における中間体として有用であるピリミジニルシクロペンタン化合物の調製方法を提供すること。【解決手段】金属触媒を用いた非対称水素化により製造される光学活性なカルボン酸誘導体と、酸化還元酵素によって触媒される非対称性還元により製造される光学活性なアルコール誘導体をカップリングさせる、ピリミジニルシクロペンタン化合物の調製方法である。【選択図】なし