DERIVATIVES OF AMPHOTERICIN B

• Main Authors: ARUN P THOTTUMKARA, MARTIN D BURKE, ELENA S KOLTUN, KEVIN T MELLEM, ZACHARY K SWEENEY
• Format: Patent
• Language: English; Japanese
• Published: 20.05.2021
• Subjects: CHEMISTRY; DERIVATIVES THEREOF; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; NUCLEIC ACIDS; NUCLEOSIDES; NUCLEOTIDES; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SUGARS

To provide amphotericin B (AmB) as a form or a derivative that is effective against fungal infections and less toxic.SOLUTION: The invention provides a compound represented by a formula (I) in the figure or a pharmacologically acceptable salt thereof. In the formula, X is -O- or the like; R1 is substituted or unsubstituted alkyl or the like; and R5 is alkyl or the like.SELECTED DRAWING: None 【課題】真菌感染症に対して有効であって、しかも毒性が少ない形態または誘導体になったアムホテリシンＢ（ＡｍＢ）を提供する。【解決手段】式（Ｉ）［Ｘ：−Ｏ−等；Ｒ１：置換もしくは未置換のアルキル等；Ｒ５：アルキル等］で表される化合物またはその薬理学的に許容される塩を提供する。【選択図】なし